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This study characterizes humoral and T cell responses to the BNT162b2 vaccine. It establishes a rapid 11-day ex-vivo expansion protocol for spike-specific T cells using G-Rex 10 devices, demonstrating significant fold expansion and functional enhancement for potential adoptive immunotherapy.

High-throughput screening identified a small molecule, GSK2622391, that enhances lentiviral transduction efficiency in T cells. The compound improves vector copy number without negatively impacting cell viability or function. G-Rex plates were used for T cell expansion during small-scale validation experiments.

The study shows that overexpression of an engineered PGC-1α improves the metabolic fitness and anti-tumor efficacy of CAR-T cells. During in vitro culture, cells were transferred to G-Rex 6M Well Plates for rapid expansion.

This review covers various bioreactor systems for red blood cell production. It specifically references the use of G-Rex for the expansion of peripheral blood mononuclear cells (PB MNCs) in its summary of 3D scaffolds and bioreactors.

The study demonstrates that CoStAR, a chimeric costimulatory receptor, enhances the effector function of T cells and TILs. Transgene-expressing cells and TILs were expanded using G-Rex plates, including G-Rex 6M, as part of the rapid expansion protocol.

This review summarizes the current landscape of CAR T-cell therapy for mantle cell lymphoma. It discusses manufacturing processes, noting that selection, activation, transduction, and expansion steps are often performed in systems such as G-Rex bottles.

This research explores the mechanisms of immune evasion related to CD58 loss and PD-L1 upregulation. Patient-derived TILs and CRISPR-engineered T cells used in the experiments were expanded using G-Rex 10 and G-Rex 100 bottles.

The authors demonstrate a method to generate CAR-NK cells using mRNA-LNP transfection. The NK cells used in the study were cultured and expanded in G-Rex 6-well and 24-well plates.

This study investigates the role of CDK6 and PTPs in regulating T cell activity and immunotherapy resistance. CD19-CAR T cells used in the study were expanded in G-Rex 10 and G-Rex 100 to generate sufficient cell numbers.

This phase 1 trial used non-viral CRISPR-Cas9 editing to replace endogenous TCRs with personalized neoantigen-specific TCRs in T cells. Clinical-grade manufacturing of the neoTCR T cell products included activation and expansion steps performed in G-Rex 100M CS

This paper presents a novel macroencapsulation device for islet transplantation to treat type 1 diabetes. While the study focuses on device engineering, it references previous work utilizing G-Rex technology for cell culture applications.

The authors describe a manufacturing process for expanding virus-specific CD8+ T cells from vaccinated macaques. The final co-culture of T cells, PHA blasts, and feeder cells was rapidly expanded in G-Rex 100 for one week.