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Case Studies

Transition to Closed-system T Cell Expansion Leads to Process Optimization

In this case study, ScaleReady helped an autologous T cell therapy company rapidly transition to a closed-system process for cell expansion by providing a testing plan to verify that G-Rex500M-CS closed-system bioreactors would meet their immediate cell production requirements and improve cell production efficiency, while adhering to their short timelines for going into clinical trials. In doing so, the company also uncovered small changes to their cell culture protocols that made a big impact on their cell production efficiency.
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Case Studies

Forecasting a Commercially Viable T Cell Therapy Manufacturing Process

In this case study, a company requested help from ScaleReady to build business case for G-Rex®500M-CS bioreactors as the primary cell production platform for their autologous TCR T cell therapy pipeline. ScaleReady modeled operational costs for an autologous TCR T cell therapy company using G-Rex bioreactors. This provided transparency into long-term commercial viability of the ScaleReady platform.
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Case Studies

GMP Cytokines Optimization for Closed System T Cell Therapy Manufacturing

In this case study, a company focused on autologous T cell therapies targeting solid tumor cancers was progressing into clinical trials and needed to transition from research-grade to GMP-grade cytokines. Concurrently they wanted to improve their methods of cytokine supplementation to reduce cytokine waste, improve dose accuracy across lots, and reduce process risk by defining methods for closed-system cytokine addition. ScaleReady detailed a plan to help them achieve these goals.
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Videos

Future of T Cell Manufacturing using G-Rex Closed-system Bioreactors

This video animation demonstrates a vision toward the industrialization and automation of T cell therapy manufacturing using G-Rex Bioreactors.

Video was created by Wilson Wolf Manufacturing Corporation.
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Literature

G-Rex Closed-system Bioreactors

In this brochure you will learn how G-Rex bioreactors solve the limitations of flask and bag-based cell therapy manufacturing. In this brochure:
  • G-Rex Bioreactor mechanism of action
  • Benefits for cell therapy manufacturing
  • GatheRex Cell Harvest Pump
  • User testimonials
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Videos

G-Rex – Revolutionizing Cell Therapy Manufacturing

In this video you will learn how G-Rex bioreactors solve the limitations of flask and bag-based cell therapy manufacturing. By providing cells with uninterrupted access to oxygen and nutrients, the G-Rex cell culture device is the only accessible cell expansion technology that linearly scales to meet the demands of cell therapy manufacturers.
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Videos

On Demand Symposium: Defining Intelligent Scale-up and Scale-out

In this recorded symposium, cell therapy manufacturing leaders speak about defining and planning for intelligent commercial scale up and scale out. Recorded at ISCT 2021.
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Literature

Cell Processing Systems Comparison Flyer

Compare Lovo and Cue system specifications and applications.
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Literature

TcBuster Non-viral Genetic Engineering Flyer

TcBuster non-viral gene editing solves the bottlenecks facing viral vector-based editing, including supply chain, manufacturing time, and integration safety. In this flyer:
  • How TcBuster works
  • Comparison to viral tranduction
  • Data on transposition efficiency and scalability
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Literature

ExCellerate Media for Immune Cells

This flyer provides details and data for our T cell and NK cell versions of ExCellerate media.
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Literature

Cloudz Cell Activation and Expansion Kits Flyer

This flyer provides details and data for T cell, Treg, and NK cell Cloudz Activation Kits.
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Literature

Cue Cell Processing System Brochure

Cue Cell Processing System is the definitive instrument for small volume cell processing for cell therapy. In this brochure:
  • Instrument Features
  • Applications supported
  • Customizable protocol design
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