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Case Studies

Lovo Integral to COVID-19 Lung Fibrosis Clinical Trial

In this case study we interview Arindam Mitra, Head of Advanced Therapies Manufacturing at Guy's and St. Thomas, Biomedical Research Center, on their use of the Lovo cell processing system to support manufacturing of a COVID-19 cell therapy to treat lung fibrosis. This cell therapy is currently in clinical trials. A BBC video describing the manufacturing procedure and treatment impact on one patient is included.
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Literature

DXT Data Management System for Lovo

This flyer discusses the benefits of automating your documentation with Lovo DXT. Lovo DXT Data Management is an open-architecture software platform supported by our team of networking specialists. Lovo DXT supports 21 CFR Part 11 compliance.
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Literature

GMP Cytokines for T Cell and NK Cell Manufacturing

GMP cytokines are critical raw materials for T cell and NK cell therapy manufacturing. Variability in lot-to-lot consistency can impact product reproducibility and increase risk of product failure, while inability to secure clinical-trial size lots of cytokine can sideline manufacturing and clinical trial progress. This flyer details how ScaleReady is offers GMP cytokines that alleviate these risks.
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Literature

Recombinant Human IL-7 GMP

GMP-grade Recombinant Human IL-7 can now be produced at a game-changing scale within Bio-Techne’s new dedicated animal-free GMP facility. This flyer details manufacturing benefits and product specifications for GMP IL-7, including comparison to animal-free research-grade rhIL-7 to enable a seamless transition to GMP.
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Case Studies

Transition to Closed-system T Cell Expansion Leads to Process Optimization

In this case study, ScaleReady helped an autologous T cell therapy company rapidly transition to a closed-system process for cell expansion by providing a testing plan to verify that G-Rex500M-CS closed-system bioreactors would meet their immediate cell production requirements and improve cell production efficiency, while adhering to their short timelines for going into clinical trials. In doing so, the company also uncovered small changes to their cell culture protocols that made a big impact on their cell production efficiency.
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Case Studies

Forecasting a Commercially Viable T Cell Therapy Manufacturing Process

In this case study, a company requested help from ScaleReady to build business case for G-Rex®500M-CS bioreactors as the primary cell production platform for their autologous TCR T cell therapy pipeline. ScaleReady modeled operational costs for an autologous TCR T cell therapy company using G-Rex bioreactors. This provided transparency into long-term commercial viability of the ScaleReady platform.
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Case Studies

GMP Cytokines Optimization for Closed System T Cell Therapy Manufacturing

In this case study, a company focused on autologous T cell therapies targeting solid tumor cancers was progressing into clinical trials and needed to transition from research-grade to GMP-grade cytokines. Concurrently they wanted to improve their methods of cytokine supplementation to reduce cytokine waste, improve dose accuracy across lots, and reduce process risk by defining methods for closed-system cytokine addition. ScaleReady detailed a plan to help them achieve these goals.
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Videos

Future of T Cell Manufacturing using G-Rex Closed-system Bioreactors

This video animation demonstrates a vision toward the industrialization and automation of T cell therapy manufacturing using G-Rex Bioreactors.

Video was created by Wilson Wolf Manufacturing Corporation.
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Literature

G-Rex Closed-system Bioreactors

In this brochure you will learn how G-Rex bioreactors solve the limitations of flask and bag-based cell therapy manufacturing. In this brochure:
  • G-Rex Bioreactor mechanism of action
  • Benefits for cell therapy manufacturing
  • GatheRex Cell Harvest Pump
  • User testimonials
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Videos

G-Rex – Revolutionizing Cell Therapy Manufacturing

In this video you will learn how G-Rex bioreactors solve the limitations of flask and bag-based cell therapy manufacturing. By providing cells with uninterrupted access to oxygen and nutrients, the G-Rex cell culture device is the only accessible cell expansion technology that linearly scales to meet the demands of cell therapy manufacturers.
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Videos

On Demand Symposium: Defining Intelligent Scale-up and Scale-out

In this recorded symposium, cell therapy manufacturing leaders speak about defining and planning for intelligent commercial scale up and scale out. Recorded at ISCT 2021.
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Literature

Cell Processing Systems Comparison Flyer

Compare Lovo and Cue system specifications and applications.
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