Recombinant Human IL-2 Protein GMP Animal-Free

GMP-Grade Animal-Free Recombinant Human IL-2 for Cell Therapy Manufacturing


IL-2 RUO and GMP Animal-Free Cytokines

We source Bio-Techne R&D Systems RUO and GMP-grade IL-2, which contains the same cysteine to serine mutation found in Proleukin®.  This mutation has been reported to prevent cysteine mispairing in E. coli, which can lead to protein aggregation and make our new GMP-grade IL-2 protein soluble in injectable-grade water.

CGT researchers use IL-2 GMP proteins to promote the proliferation of CAR-T cells, TCR T cells, Tregs, TILs, and NK and CIK cells. Our Animal-Free GMP-grade cytokines boast robust reproducible bioactivity and confidence in RUO to GMP translation that will accommodate closed-system requirements as you progress through clinical trials.

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Dedicated Facility - USA Based

Working with Bio-Techne R&D proteins means working with truly animal-free devoid of animal contaminants and mammalian pathogens.  Our proteins are produced in the only publicly known state-of-the-art certified animal-free facility at our St. Paul, Minnesota, USA headquarters. Animal-free certificates of origin are available, and traceable batch records are kept for all our recombinant human GMP cytokines.

Have confidence in your cytokines to meet the growing industry demand and the needs of your program from process development to commercialization.  The new facility is not only animal-free, it has been optimized for scale to address these challenges.

No More Reconsitution! Save Time with Liquid Cytokines!

  • Streamlined Process: Save time and materials – no reconstitution
  • Increased Reproducibility: Eliminate errors with reconstitution steps
  • Equivalent Bioactivity: Easily substitute for lyophilized proteins
  • Stability: Rely on full bioactivity for at least six months as supplied.

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Save Precious Time and Burn Less Cash

Prevent the time lost and money invested in re-qualifying lots.  Entire lots of our animal-free IL-2 can be reserved to accommodate your long-term program needs all while being rigorously tested to ensure consistency with previous lots and master lots so your confidence in product continuity remains high.

Test our IL-2 Cytokines
RUO to GMP il-2 bioassay chart

Animal Free IL-2 RUO to GMP Scalable, Seamless Translation

Scaling up from research to clinical can present many challenges, but your confidence in cytokine performance shouldn’t be one of them. Your program needs supply chain security, and assurance of consistent RUO to GMP bioactivity all while moving with speed and efficiency… and to do so shouldn’t have any compromise.

High bioactivity and low lot-to-lot variability mean confidence in your cytokine experiments that are reproducible over time, speeding up the entire process all while lowering overall risk.

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Choose IL-2 Cytokine Formats that Fit Your Need

Bio-Techne GMP cytokines are available in off-the-shelf vials in 50μg, 1mg sizes, and custom mass/vial (liquid or lyophilized).

Secure your IL-2 RUO or GMP animal-free proteins today, fill out the form below to test cytokines in your program and we’ll be in touch!

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How to order

Fill out the form below or contact us directly to place an order or consult with a ScaleReady expert.
Phone: 651-628-9259
Fax: 651-628-9507


Don’t cut corners on the cost of raw materials. Select high quality raw materials from the beginning.
- Michael Paglia
Chief Operating Officer
Elevate Bio, BaseCamp

Additional GMP Cytokine resources

GMP Cytokines Optimization for Closed System T Cell Therapy Manufacturing

In this case study, a company focused on autologous T cell therapies targeting solid tumor cancers was progressing into clinical trials and needed to transition from research-grade to GMP-grade cytokines. Concurrently they wanted to improve their methods of cytokine supplementation to reduce cytokine waste, improve dose accuracy across lots, and reduce process risk by defining methods for closed-system cytokine addition. ScaleReady detailed a plan to help them achieve these goals.

Determining Optimal Seeding Density for Human T Cell Expansion in G-Rex

This scientific poster investigates the kinetics of human T cell expansion in small scale G-Rex6M bioreactors using ScaleReady reagents. Data show the affect of seeding density on fold expansion, total cell yield, and phenotypic phenotypic composition of expanded T cells, including total and memory CD4+ and CD8+ cells.

IL-2, IL-7 and IL-15 Cytokines Brochure

IL-2, IL-7, and IL-15 are critical cytokine components to many successful T and NK cell therapy programs.  Choosing these cytokines from a partner that can offer seamless translation from RUO to GMP means that the consistency across lots, the confidence in bioactivity, and cost-effectiveness are no longer barriers to manufacturing with consistency, translating with speed and scaling without limitation.  Learn more about these powerhouse cytokines in this brochure.

See how GMP Cytokines fit into the ScaleReady™ workflow.