Targeting triple-negative breast cancer using cord-blood CD34⁺ HSPC-derived mesothelin-specific CAR-NKT cells with potent antitumor activity
This study develops Allo15MCAR-NKT cells from gene-engineered cord-blood CD34+ HSPCs to target triple-negative breast cancer. The NKT cells home to lungs and bone marrow, reprogram the immunosuppressive tumor microenvironment, and safely suppress metastatic tumors. G-Rex is not referenced in this document.
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