T cell receptor gene therapy targeting KRAS G12V for advanced pancreatic cancer in a single-arm phase 1/2 clinical trial
Single-arm phase 1/2 trial NCT04146298 treated five recurrent pancreatic cancer patients with autologous T cells engineered with an HLA-A*11:01-restricted KRAS G12V TCR; three had repeat infusions. Products were rapidly expanded in G-Rex 500 flasks and rested in G-Rex 24-well plates (Wilson Wolf).
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Cell therapies are exploding with potential, offering groundbreaking new treatments for a wide range of diseases. Yet, a central challenge lies in bringing these complex therapies out of the lab and into the real world. In a recent panel discussion, Josh Ludwig (Global Commercial Director, ScaleReady) and Stuart Curbishley (Chief Manufacturing & Development Officer, Adthera Bio) shed light on this complex transition.
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