A TGF-βR/IL-2R immunomodulatory fusion protein transforms immunosuppression into T cell activation to enhance adoptive T cell therapy
Chimeric TGF-betaR/IL-2R fusion proteins convert suppressive TGF-beta signals into IL-2 proliferative signals. Engineered CD8+ T cells kept stemness and killed tumors better when paired with a mesothelin TCR. Transduced cells were moved to G-Rex gas-permeable 24-well vessels to expand.
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Cell therapies are exploding with potential, offering groundbreaking new treatments for a wide range of diseases. Yet, a central challenge lies in bringing these complex therapies out of the lab and into the real world. In a recent panel discussion, Josh Ludwig (Global Commercial Director, ScaleReady) and Stuart Curbishley (Chief Manufacturing & Development Officer, Adthera Bio) shed light on this complex transition.
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