HLA-A2 CAR/IL-2-CISC engineered Treg display robust in vitro and in vivo antigen-specific regulatory function
HDR editing at the FOXP3 locus created A2CAR engineered Treg carrying an inducible IL-2 signaling complex. The cells kept a Treg phenotype, stayed minimally cytotoxic, and beat polyclonal EngTreg in a xenogeneic GvHD model. Expansion used G-Rex gas-permeable culture systems.
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