NOT gated T cells that selectively target EGFR and other widely expressed tumor antigens
This study describes Tmod cell therapy using a NOT gate to target widely expressed antigens like EGFR while sparing normal cells via an HLA-A*02 blocker. Primary T cells were transduced with CAR or Tmod lentivirus and cultured in G-Rex plates (G-Rex 10 for in vivo studies) to generate effector cells.
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