IL2 Targeted to CD8+ T Cells Promotes Robust Effector T-cell Responses and Potent Antitumor Immunity
This study describes AB248, a CD8 cis-targeted IL2 that selectively activates CD8+ T cells. B7H3 CAR-T cells were generated by stimulating T cells and transducing them in a 24-well G-Rex plate. The combination of CAR-T and CD8-targeted IL2 resulted in potent antitumor activity and complete tumor rejection in mice.
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Let’s talk more about how ScaleReady can advance your cell and gene therapy research and manufacturing with ingenious efficiency.