A Simple and Robust Single-Step Method for CAR-Vd1 gdT Cell Expansion and Transduction for Cancer Immunotherapy
The authors describe a robust method for expanding Vd1 gamma-delta T cells using OKT-3 and IL-15. Culture in 6-well G-Rex vessels supported >1000-fold expansion in some donors. The expanded Vd1 cells were efficiently transduced with CARs and demonstrated potent antigen-specific cytotoxicity.
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Cell therapies are exploding with potential, offering groundbreaking new treatments for a wide range of diseases. Yet, a central challenge lies in bringing these complex therapies out of the lab and into the real world. In a recent panel discussion, Josh Ludwig (Global Commercial Director, ScaleReady) and Stuart Curbishley (Chief Manufacturing & Development Officer, Adthera Bio) shed light on this complex transition.
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