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The study analyzes T-Ag-reactive CD8+ T cells in Merkel cell carcinoma patients treated with anti-PD1. Responders showed broader T-cell recognition. T-Ag-specific T cells were expanded from PBMCs using artificial Ag-presenting scaffolds in G-Rex 24 well plates to enhance tumor killing.

This study demonstrates that human keratinocytes cultured on a gas-permeable interface (GPI) stratify to form a mature epidermis, comparable to the air-liquid interface method. G-Rex 6 well plates were used as the GPI device for culturing the keratinocytes and inducing stratification.

A case report detailing the treatment of refractory DLBCL using CIK cells combined with obinutuzumab. The therapy achieved a very good partial remission without severe toxicity. CIK cells were produced and expanded for 14 days in G-Rex using a blinatumomab-based protocol.

The study develops allogeneic "Smart CAR T cells" using TALEN gene editing. These cells constitutively express a FAP CAR to target CAFs, which induces mesothelin CAR expression. This logic-gated approach improves solid tumor efficacy and safety. G-Rex 6M plates were used for the expansion of gene-edited T cells.

This study investigates the specificity of the MR1-restricted TCR from clone MC.7.G5. Results show recognition is restricted to the MR1*04 allomorph and is not cancer-specific, reacting to healthy cells expressing MR1*04. G-Rex systems were used to seed and expand CD3+ T cells during the transduction process.

This study demonstrates that the 4-1BBζ costimulatory domain enhances CD8+ T-cell proliferation and cytokine production following TCR stimulation compared to CD28ζ. CAR T-cells were manufactured and expanded in G-Rex plates for 13 days prior to functional analysis.

This study assesses TIL expansion from HNSCC samples, finding sTIL percentage as a key predictor. A subset of samples underwent a Rapid Expansion Protocol (REP) using either T-flasks or G-Rex vessels, achieving high fold expansion.

This paper describes a virus-free CAR-T manufacturing process using the Quantum pBac system and Quantum Booster supplement. Use of G-Rex 24-well and 1L vessels allowed for the generation of clinically relevant numbers of high-quality CAR-TSCM cells in 10 days.

The study demonstrates that HSPC-derived CAR-T cells exhibit superior persistence and viral control compared to adoptively transferred T cells in HIV models. The adoptive CAR-T cell products were manufactured and expanded for ~7 days in G-Rex.

This study shows that modulating glucose/glutamine during activation and expansion (metabolic priming) improves TRAC-CAR T cell stemness and in vivo persistence. Expansion of the gene-edited cells was performed in G-Rex 6M plates.

The researchers designed a split-signaling bispecific CAR to target AML cells while sparing HSCs. CAR T cells were expanded using G-REX plates to generate sufficient cell numbers for in vivo xenograft experiments comparing bispecific and monospecific CARs.

This study identifies that GZMB leakage causes apoptosis in cryopreserved NK cells and that IL-15/IL-18 pretreatment mitigates this. NK cells were isolated and expanded for 15-20 days in G-Rex 6-well plates using irradiated K562 feeder cells.