Phase II clinical trial of adoptive cell therapy for patients with metastatic melanoma with autologous tumor-infiltrating lymphocytes and low-dose interleukin-2
A Phase II study evaluating low-dose IL-2 with TILs for metastatic melanoma. 12 patients treated with non-myeloablative chemotherapy and TILs expanded in G-Rex100. Two partial responses and one unconfirmed PR were observed. Low-dose IL-2 was feasible but resulted in lower response rates compared to high-dose regimens.
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