Manufacturing NKG2D CAR-T cells with piggyBac transposon vectors and K562 artificial antigen-presenting cells
This paper details a manufacturing process for NKG2D CAR-T cells using piggyBac vectors and K562 aAPCs. It demonstrates robust expansion and cytotoxicity. While the specific protocol uses T75 flasks, it cites previous work utilizing G-Rex vessels for large-scale T cell expansion.
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