IL-2-armored peptide-major histocompatibility class I bispecific antibodies redirect antiviral effector memory CD8+ T cells to induce potent anti-cancer cytotoxic activity with limited cytokine release
This study presents IL-2-armored GPS molecules that selectively expand and redirect CMV-specific CD8+ T cells. Expansion assays were conducted in 6-well and 24-well G-REX plates. The approach induced potent cytotoxicity against cancer cells with a reduced cytokine release profile compared to conventional TCEs.
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