Generating universal anti-CD19 CAR T cells with a defined memory phenotype by CRISPR/ Cas9 editing and safety evaluation of the transcriptome
This study presents a method to generate universal CAR-T cells with a defined memory phenotype by editing TRAC and B2M genes. Cells were cultured in G-Rex 24-well plates. The safety of the editing was confirmed via CRISPRroots analysis, and the cells showed effective anti-tumor activity in vitro.
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