“Cerberus” T Cells: A Glucocorticoid-Resistant, Multi-Pathogen Specific T Cell Product to Fight Infections in Severely Immunocompromised Patients
The authors generated "Cerberus" T cells (Cb-STs) targeting multiple viruses and Aspergillus fumigatus, with CRISPR/Cas9-mediated glucocorticoid receptor disruption. G-Rex10 devices were used for the culture and expansion of these multi-pathogen specific T cells. Cb-STs maintained function in the presence of dexamethasone.
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