CD147-CAR-NK cell therapy shows minimal toxicities in human CD147 transgenic mouse model with solid tumors
The study investigates the toxicity of CD147-CAR-NK therapy in a human CD147 transgenic mouse model. NK cells were expanded and transduced in G-Rex plates. Results indicate minimal on-target/off-tumor toxicities and less neuroinflammation compared to CAR-T therapy, supporting clinical potential.
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