BOXR1030, an anti-GPC3 CAR with exogenous GOT2 expression, shows enhanced T cell metabolism and improved anti-cell line derived tumor xenograft activity
The authors developed BOXR1030, a GPC3-targeted CAR T cell co-expressing GOT2 to enhance metabolism. T cells were expanded in G-Rex 10 or 100 units. BOXR1030 demonstrated superior in vivo antitumor activity, reduced exhaustion, and better persistence in solid tumor xenograft models compared to control CARs.
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