G-Rex for Natural Killer (NK) and CAR-NK cell therapies.
G-Rex devices are routinely used in the clinical (GMP) production of Natural Killer cells, both unmodified and gene-modified (CAR or TCR-NK), because of their simplicity, scalability, and robustness. Titans of NK cell therapy, including pioneers at Baylor College of Medicine and the M.D. Anderson Cancer Center, have used G-Rex to produce therapeutic NK cell drug product for over a decade.
NK cell therapy leaders choose G-Rex
Dr. Austin Bigley
For decades the titans of NK cell therapy have chosen G-Rex as their preferred platform. Hear from Dr. Austin Bigley, VP of R&D at Indapta Therapeutics, present at the Texas Medical Center regarding how Indapta Therapeutics is bringing hope to cancer patients through G-Rex and natural killer cell therapy.
Process Development & Manufacturing
Developers like Senti Bio leverage the G-Rex’s linear scalability to efficiently scale up/down and scale out.
See the poster Senti presented highlighting a linearly scalable CAR-NK cell therapy process.
Investigators like those at the University of Minnesota leverage the G-Rex’s simplicity and robust expansion capacity to efficiently produce large quantities of high-quality CAR-NK cells
See the manuscript illustrating a non-viral CAR-NK cell manufacturing process.
G-Rex® for γδ T cell therapy
G-Rex® for Natural Killer T (NKT) cell therapy
NKT cell therapy leaders choose G-Rex.
Leading investigator Dr. Lili Yang and her team at UCLA describe in a recent Nature Biotech article how to differentiate and expand CAR-NKT cells with high-yield, purity, antitumor efficacy, and persistence using G-Rex devices.
Dr. Leonid Metelitsa, a pioneer of NKT cell therapy at Baylor College of Medicine, has published extensively on the autologous and allogeneic use of NKT cell therapy to treat a variety of cancers. In a recent Molecular Therapy article, Dr. Metelitsa and his team describe how to generate better NKT cells through the use of IL-18. At the heart of the their NKT cell culture protocol is G-Rex.
